Diabetes - NAD Nutritional Support: Cerebrospinal fluid lactate in patients with diabetes mellitus and hypoglycaemic coma.

Cerebrospinal fluid lactate in patients with diabetes mellitus and hypoglycaemic
coma.
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Diabetes on 26/03/2011 12:36:00

CSF lactate was slightly but significantly higher in diabetes mellitus

Cerebrospinal fluid (CSF) lactate and pyruvate concentrations were determined in
20 patients with diabetes mellitus but without disturbance of consciousness and
five who recovered from hypoglycaemic coma.
CSF lactate was slightly but significantly higher in diabetes mellitus (1.78,
SEM 0.04 m mol/l) than that in 15 control subjects (1.40, SEM 0.05 m mol/l). In
those who recovered from hypoglycaemic coma, CSF lactate was markedly elevated
to 2.45-4.43 m mol/l. CSF glucose concentrations, however, were substantially
the same between treated hypoglycaemic and diabetes mellitus groups.
These findings indicate that CSF lactate levels increase with glycaemic levels
in diabetes mellitus owing to enhanced glucose influx into glycolytic pathway of
the brain, and also increases in treated hypoglycaemic coma probably due to
mitochondrial dysfunction or damage.
About the Authors
Yao H, Sadoshima S, Nishimura Y, Fujii K, Oshima M, Ishitsuka T, Fujishima M.
(1989) Cerebrospinal fluid lactate in patients with diabetes mellitus and
hypoglycaemic coma. J Neurol Neurosurg Psychiatry. 1989 Mar;52(3):372-5. Second
Department of Internal Medicine, Faculty of Medicine, Kyushu University,
Fukuoka, Japan.