Diabetes - NAD Nutritional Support: Nicotinamide and Prevention of Insulin-dependent Diabetes Mellitus.

Nicotinamide and Prevention of Insulin-dependent Diabetes Mellitus.
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Diabetes on 26/03/2011 12:29:00

Nicotinamide increases the intracellular NAD pool, thus increasing the energy
supply of the cell.

As a result of beta cell destruction, islet cell antibodies (ICA) can be
demonstrated in the circulation. These antibodies can be detected up to eight
years prior to overt IDDM.
Nicotinamide, a vitamin B3 derivative, interferes with the immune mediated
beta-cell destruction by reducing the content of FR and NO and thereby reducing
their deleterious effects.
At the same time, nicotinamide increases the intracellular NAD pool, thus
increasing the energy supply of the cell. Nicotinamide protects against
chemically induced as well as spontaneous diabetes in animal models of the
disease.
Recently, open clinical studies have suggested that nicotinamide when
administered to humans can prevent or delay clinical onset of IDDM.
About the Authors
Reimers JI, Andersen HU, Pociot F. (1994). Nicotinamide and Prevention of
Insulin-dependent Diabetes Mellitus. Rationale, Effects, Toxicology and Clinical
Experiences ENDIT Group. Ugeskr Laeger 1994 Jan 24;156(4):461-5. Steno Diabetes
Center, Gentofte.