Articles
The elevation of blood lactate is associated with a greater carbohydrate oxidation in type 2 diabetes
These results show that the elevation of blood lactate is associated with a greater carbohydrate oxidation in type 2 diabetes ... Full story
The burden of diabetic foot ulcers.
Results of etiologic studies suggest that hyperglycemia induces diabetes-related complications through sorbitol accumulation and protein glycation ... Full story
Cerebrospinal fluid lactate in patients with diabetes mellitus and hypoglycaemic coma.
CSF lactate was slightly but significantly higher in diabetes mellitus ... Full story
Diabetic neuropathies. Metabolism of sorbitol in sciatic nerve tissue in streptozotocin diabetes.
Nicotinamide as a precursor of NAD+ biosynthesis increased the free NADP+/NADPH and NAD+/NADH ratios and inhibited the activity of polyol pathway. ... Full story
Pyridine nucleotides in glucose metabolism and diabetes: a review.
Therapy with NAD precursors like nicotinamide might have corrective effects on these proposed biochemical aberrations, thereby retarding progression of microangiopathy. ... Full story
Molecular Mechanisms of Beta-cell Destruction in Iddm: the Role of Nicotinamide.
No serious side effects have been reported from its use at the doses proposed in man or other species. ... Full story
Nicotinamide and Prevention of Insulin-dependent Diabetes Mellitus.
Nicotinamide increases the intracellular NAD pool, thus increasing the energy supply of the cell. ... Full story
Hyperglycemic Pseudohypoxia and Diabetic Complications.
In hyperglycemic tissues these vascular changes also are linked to an increased ratio of NADH/NAD, in this case because of an increased rate of reduction of NAD to NADH. ... Full story
Free NAD(+):NADH ratios in mitochondrial cristae, matrix and cytosol were decreased in diabetic rats
Neither NAD-redox and energy states nor lipid aldehyde and reduced gluthathione concentrations were affected by treatment with the inhibitor in control rats. ... Full story
Effect of nicotinamide on the uptake and release of serotonin and GABA by cerebral cortex synaptosomes in rats with diabetes
The modulating effect of in vivo administered NAm acts via NAD which binds specifically with synaptic membranes. It has been shown that brain NAD(P)/NAD(P)H decreased while sorbitol level increased ... Full story
The use of nicotinamide in the prevention of type 1 diabetes.
Other effects of the vitamin are more likely, e.g., increase in NAD pool size by de novo synthesis, or inhibition of free radical generation ... Full story
Elevated glucose levels increase retinal glycolysis and sorbitol pathway metabolism. Implications for diabetic retinopathy.
Elevation of retinal glucose levels causes a hypoxia-like redox imbalance ... Full story
Changes in the redox state in the retina and brain during the onset of diabetes in rats.
These concentrations led to a significant and progressive decrease in the NAD+/NADH ratio, suggesting that altered glucose metabolism is an initial step of retinopathy. ... Full story
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The burden of diabetic foot ulcers.
Results of etiologic studies suggest that hyperglycemia induces diabetes-related complications through sorbitol accumulation and protein glycation ... Full story
- Nicotinamide and Prevention of Insulin-dependent Diabetes Mellitus.
- Free NAD(+):NADH ratios in mitochondrial cristae, matrix and cytosol were decreased in diabetic rats
- It Runs in The Family (2003)
- Elevated glucose levels increase retinal glycolysis and sorbitol pathway metabolism. Implications for diabetic retinopathy.