Hyperglycemic Pseudohypoxia and Diabetic Complications.
In hyperglycemic tissues these vascular changes also are linked to an increased ratio of NADH/NAD, in this case because of an increased rate of reduction of NAD to NADH.... Full story
Free NAD(+):NADH ratios in mitochondrial cristae, matrix and cytosol were decreased in diabetic rats
Neither NAD-redox and energy states nor lipid aldehyde and reduced gluthathione concentrations were affected by treatment with the inhibitor in control rats. ... Full story
Effect of nicotinamide on the uptake and release of serotonin and GABA by cerebral cortex synaptosomes in rats with diabetes
The modulating effect of in vivo administered NAm acts via NAD which binds specifically with synaptic membranes. It has been shown that brain NAD(P)/NAD(P)H decreased while sorbitol level increased ... Full story
Elevated glucose levels increase retinal glycolysis and sorbitol pathway metabolism. Implications for diabetic retinopathy.
Elevation of retinal glucose levels causes a hypoxia-like redox imbalance ... Full story
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It Runs in The Family (2003)
Wife of Kirk Douglas character has diabetes and is on dialysis.
- Click (2006)
- Chocolat (2000)
- Bread & Roses (2000)
- The elevation of blood lactate is associated with a greater carbohydrate oxidation in type 2 diabetes
- The burden of diabetic foot ulcers.
- Cerebrospinal fluid lactate in patients with diabetes mellitus and hypoglycaemic coma.
- Diabetic neuropathies. Metabolism of sorbitol in sciatic nerve tissue in streptozotocin diabetes.
- Pyridine nucleotides in glucose metabolism and diabetes: a review.
- Molecular Mechanisms of Beta-cell Destruction in Iddm: the Role of Nicotinamide.
- Nicotinamide and Prevention of Insulin-dependent Diabetes Mellitus.
- Brokedown Palace
- Nothing in Common (1986)
- The use of nicotinamide in the prevention of type 1 diabetes.
- Changes in the redox state in the retina and brain during the onset of diabetes in rats.
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Nicotinamide and Prevention of Insulin-dependent Diabetes Mellitus.
Nicotinamide increases the intracellular NAD pool, thus increasing the energy supply of the cell. ... Full story